Therapy Detail

Therapy Name AMG 232 + Irinotecan
Therapy Description


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Drug Name Trade Name Synonyms Drug Classes Drug Description
AMG 232 AMG-232 MDM2 Inhibitor 17 AMG 232 is a potent inhibitor of the MDM2-p53 interaction, and inhibits proliferation of tumor cells in a p53 dependent manner (PMID: 24456472).
Irinotecan Camptosar CPT-11|Onivyde TOPO1 inhibitor 7 Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death (NCI Drug Dictionary). Camptosar (irinotecan) is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS mut + TP53 wild-type colorectal cancer sensitive AMG 232 + Irinotecan Preclinical - Cell line xenograft Actionable In a preclinical study, the combination of AMG 232 and Camptosaur (irinotecan) inhibited tumor growth in a TP53 wild-type colorectal cancer cell line xenograft model, which also harbors a KRAS mutation, with increased efficacy over either agent alone (PMID: 25567130). 25567130
Clinical Trial Phase Therapies Title Recruitment Status