Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Rigosertib Sodium
Trade Name
Synonyms ON 01910.Na|SyB L-1101
Drug Descriptions

Rigosertib (ON 01910.Na) inhibits polo-like kinase 1 (Plk1) and PI3K pathways, which induces selective G2/M arrest and apoptosis in tumor cells (PMID: 24777753).

DrugClasses PI3K Inhibitor (Pan) 40 PLK1 Inhibitor 18
CAS Registry Number 592542-60-4
NCIT ID C71355


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Gemcitabine + Rigosertib Sodium Gemcitabine Rigosertib Sodium 0 0
Palbociclib + Rigosertib Sodium Palbociclib Rigosertib Sodium 0 0
Rigosertib Sodium Rigosertib Sodium 6 4

Additional content available in CKB BOOST