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Therapy Name | Adagrasib + Palbociclib |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Adagrasib | MRTX849|MRTX-849|MRTX 849 | KRAS G12C inhibitor 23 | Adagrasib (MRTX849) covalently binds to and stabilizes GDP-bound KRAS G12C, therefore prevents KRAS downstream signaling, resulting in tumor growth inhibition (PMID: 31658955). | |
Palbociclib | Ibrance | PD0332991 | CDK4/6 Inhibitor 11 | Ibrance (palbociclib) is a selective inhibitor of cyclin-dependent kinase 4 (CDK4) and 6 (CDK6) (PMID: 19874578). Ibrance (palbociclib) is approved in combination with an aromatase inhibitor in postmenopausal patients with ER-positive, ERBB2 (HER2)-negative metastatic breast cancer, and in combination with Faslodex (fulvestrant) in patients with ER-positive, ERBB2 (HER2)-negative metastatic breast cancer (FDA.gov). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT05178888 | Phase I | Adagrasib + Palbociclib | Adagrasib in Combination With Palbociclib in Patients With Advanced Solid Tumors (KRYSTAL-16) | Recruiting | USA | 0 |