Drug Detail


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Drug Name Pralsetinib
Trade Name Gavreto
Synonyms BLU667|BLU-667
Drug Descriptions

Gavreto (pralsetinib) is a small molecule inhibitor that selectively targets activated Ret, which may result in antitumor activity including inhibition of tumor growth and tumor regression (PMID: 29657135). Gavreto (pralsetinib) is FDA approved for use in patients with metastatic RET fusion-positive non-small cell lung cancer, in adult and pediatric patients 12 years of age and older with advanced or metastatic RET-mutant medullary thyroid cancer, and in adult and pediatric patients 12 years of age and older with RET fusion-positive thyroid cancer who are radioactive iodine-refractory (FDA.gov).

DrugClasses RET Inhibitor 52
CAS Registry Number 2097132-94-8
NCIT ID C132295


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Pralsetinib Afatinib Pralsetinib 0 0
Crizotinib + Pralsetinib Crizotinib Pralsetinib 0 0
Osimertinib + Pralsetinib Osimertinib Pralsetinib 0 0
Pralsetinib Pralsetinib 49 5

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