Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Molibresib
Trade Name
Synonyms I-BET762|GSK525762|GSK-525762|GSK 525762
Drug Descriptions

Molibresib (GSK525762) is a JQ1 derivative which binds to the bromodomain of BET proteins preventing their interaction with acetylated histone peptides, thus disrupting chromatin remodeling, gene expression, and cell proliferation (PMID: 24015967, PMID: 30906568, PMID: 32328561).

DrugClasses BET Inhibitor (Pan) 32
CAS Registry Number 1260907-17-2
NCIT ID C101538


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Molibresib Abiraterone Molibresib 0 1
Bortezomib + Molibresib Bortezomib Molibresib 0 0
Carfilzomib + Molibresib Carfilzomib Molibresib 0 0
Enzalutamide + Molibresib Enzalutamide Molibresib 0 1
Fulvestrant + Molibresib Fulvestrant Molibresib 0 1
Molibresib Molibresib 1 2
Molibresib + Paclitaxel + unspecified PD-L1 antibody Molibresib Paclitaxel unspecified PD-L1 antibody 0 0
Molibresib + Palbociclib Molibresib Palbociclib 0 0
Molibresib + Rucaparib Molibresib Rucaparib 0 0
Molibresib + Selumetinib Molibresib Selumetinib 0 0

Additional content available in CKB BOOST