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Drug Name Molibresib
Trade Name
Synonyms I-BET762|GSK525762|GSK-525762|GSK 525762
Drug Descriptions

Molibresib (GSK525762) is a JQ1 derivative which binds to the bromodomain of BET proteins preventing their interaction with acetylated histone peptides, thus disrupting chromatin remodeling, gene expression, and cell proliferation (PMID: 24015967, PMID: 30906568, PMID: 32328561).

DrugClasses BET Inhibitor (Pan) 32
CAS Registry Number 1260907-17-2
NCIT ID C101538

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Molibresib Abiraterone Molibresib 0 1
Bortezomib + Molibresib Bortezomib Molibresib 0 0
Carfilzomib + Molibresib Carfilzomib Molibresib 0 0
Enzalutamide + Molibresib Enzalutamide Molibresib 0 1
Fulvestrant + Molibresib Fulvestrant Molibresib 0 1
Molibresib Molibresib 1 2
Molibresib + Paclitaxel + unspecified PD-L1 antibody Molibresib Paclitaxel unspecified PD-L1 antibody 0 0
Molibresib + Palbociclib Molibresib Palbociclib 0 0
Molibresib + Rucaparib Molibresib Rucaparib 0 0
Molibresib + Selumetinib Molibresib Selumetinib 0 0


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