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Drug Name Molibresib
Trade Name
Synonyms I-BET762|GSK525762
Drug Descriptions

Molibresib (GSK525762) is a JQ1 derivative which binds to the bromodomain of BET proteins preventing their interaction with acetylated histone peptides, thus disrupting chromatin remodeling, gene expression, and cell proliferation (PMID: 24015967, PMID: 30906568, PMID: 32328561).

DrugClasses BET Inhibitor (Pan) 27

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Molibresib Abiraterone Molibresib 0 1
Enzalutamide + Molibresib Enzalutamide Molibresib 0 1
Fulvestrant + Molibresib Fulvestrant Molibresib 0 1
Molibresib Molibresib 2 2
Molibresib + Selumetinib Molibresib Selumetinib 0 0


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