Drug Detail


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Drug Name AZD8421
Trade Name
Synonyms AZD-8421|AZD 8421
Drug Descriptions

AZD8421 selectively inhibits CDK2, potentially leading to decreased Rb1 phosphorylation, cell cycle arrest, and inhibition of proliferation and tumor growth (Cancer Res (2024) 84 (6_Supplement): 5730).

DrugClasses CDK2 Inhibitor 30
CAS Registry Number NA
NCIT ID C204103


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + AZD8421 + Camizestrant AZD8421 Abemaciclib Camizestrant 0 1
AZD8421 AZD8421 0 1
AZD8421 + Camizestrant + Palbociclib AZD8421 Camizestrant Palbociclib 0 1
AZD8421 + Camizestrant + Ribociclib AZD8421 Camizestrant Ribociclib 0 1
AZD8421 + Palbociclib AZD8421 Palbociclib 0 0

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