Drug Detail


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Drug Name Danusertib
Trade Name
Synonyms PHA-739358
Drug Descriptions

Danusertib (PHA-739358) is a pan-Aurora kinase with additional activity against ABL, FGFR1, RET, TRKA, and BCR-ABL, including the T315I mutant (PMID: 20072840, PMID: 18089710, PMID: 31625025).

DrugClasses ABL1 Inhibitor 8 AURK Inhibitor (Pan) 12 BCR-ABL Inhibitor 31 FGFR1 Inhibitor 28 RET Inhibitor 52 TrkA Receptor Inhibitor 8
CAS Registry Number 827318-97-8
NCIT ID C61587


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Danusertib Danusertib 0 0
Danusertib + Fulvestrant Danusertib Fulvestrant 0 0
Danusertib + Palbociclib Danusertib Palbociclib 2 0
Danusertib + SCH772984 Danusertib SCH772984 0 0

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