Therapy Detail

Therapy Name Bazedoxifene + Palbociclib
Synonym
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Bazedoxifene Hormone - Anti-estrogens 16 Bazedoxifene is a selective estrogen receptor modulator, which improves bone health and lipid metabolism without adverse effects on breast and uterus (PMID: 15961563).
Palbociclib Ibrance PD0332991 CDK4/6 Inhibitor 8 Ibrance (palbociclib) is a selective inhibitor of cyclin-dependent kinase 4 (CDK4) and 6 (CDK6) (PMID: 19874578). Ibrance (palbociclib) is approved in combination with an aromatase inhibitor in postmenopausal patients with ER-positive, ERBB2 (HER2)-negative metastatic breast cancer, and in combination with Faslodex (fulvestrant) in patients with ER-positive, ERBB2 (HER2)-negative metastatic breast cancer (FDA.gov).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT02448771 Phase Ib/II Bazedoxifene + Palbociclib A Study of Palbociclib in Combination With Bazedoxifene in Hormone Receptor Positive Breast Cancer Active, not recruiting