Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Merestinib
Trade Name
Synonyms LY2801653|LY-2801653
Drug Descriptions

Merestinib (LY2801653) inhibits several receptor tyrosine kinases including MET, MST1R (RON), AXL, MERTK, TYRO3, ROS1 fusions, PDGFRA, FLT3, TEK, DDR1/2, MKNK1/2, and NTRK1/2/3 with greatest activity against NTRK1, and may result in decreased tumor growth (PMID: 23275061, PMID: 24305878, PMID: 29568395, PMID: 32537847).

DrugClasses AXL Inhibitor 28 DDR1 Inhibitor 8 DDR2 inhibitor 7 FLT3 Inhibitor 61 MET Inhibitor 56 RON Inhibitor 11 ROS1 Inhibitor 19 Trk Receptor Inhibitor (Pan) 29 TYRO3 Inhibitor 8
CAS Registry Number 1206799-15-6
NCIT ID C95729

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Capmatinib + Merestinib Capmatinib Merestinib 0 0
LY2874455 + Merestinib LY2874455 Merestinib 0 1
Merestinib Merestinib 0 4
Merestinib + Ramucirumab Merestinib Ramucirumab 0 1


Additional content available in CKB BOOST