Drug Detail


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Drug Name Merestinib
Trade Name
Synonyms LY2801653|LY-2801653
Drug Descriptions

Merestinib (LY2801653) inhibits several receptor tyrosine kinases including MET, MST1R (RON), AXL, MERTK, TYRO3, ROS1 fusions, PDGFRA, FLT3, TEK, DDR1/2, MKNK1/2, and NTRK1/2/3 with greatest activity against NTRK1, and may result in decreased tumor growth (PMID: 23275061, PMID: 24305878, PMID: 29568395, PMID: 32537847).

DrugClasses AXL Inhibitor 30 DDR1 Inhibitor 10 DDR2 inhibitor 7 FLT3 Inhibitor 69 MET Inhibitor 59 RON Inhibitor 11 ROS1 Inhibitor 20 Trk Receptor Inhibitor (Pan) 31 TYRO3 Inhibitor 8
CAS Registry Number 1206799-15-6
NCIT ID C95729


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Capmatinib + Merestinib Capmatinib Merestinib 0 0
LY2874455 + Merestinib LY2874455 Merestinib 0 1
Merestinib Merestinib 0 4
Merestinib + Ramucirumab Merestinib Ramucirumab 0 1

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