Therapy Detail

Therapy Name INC280 + PDR001
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Capmatinib INC280 MET Inhibitor 50 Capmatinib (INC280) inhibits c-MET and may induce cell death in tumors over expressing c-MET or expressing constitutively activated c-MET (NCI Drug Dictionary).
PDR001 Spartalizumab Immune Checkpoint Inhibitor 99 PD-L1/PD-1 antibody 48 Spartalizumab (PDR001) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (NCI Drug Dictionary).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT02795429 Phase Ib/II PDR001 INC280 + PDR001 Phase Ib/II Study of INC280 + PDR001 or PDR001 Single Agent in Advanced HCC Recruiting
NCT03484923 Phase II LAG525 + PDR001 INC280 + PDR001 PDR001 + Canakinumab Study of Efficacy and Safety of Novel Spartalizumab Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma (PLATforM) Recruiting
NCT03647488 Phase II INC280 + PDR001 Docetaxel Study of Capmatinib and Spartalizumab Combination Therapy vs Docetaxel in Non-small Cell Lung Cancer Recruiting