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Drug Name Vactosertib
Trade Name
Synonyms EW-7197|TEW-7197|TEW 7197
Drug Descriptions

Vactosertib (TEW 7197) is a small molecule that inhibits ALK5, leading to decreased TGF-beta signaling and potentially resulting in decreased tumor cell metastasis (PMID: 24817629, PMID: 31673825)

DrugClasses TGFB inhibitor 5
CAS Registry Number 1352608-82-2
NCIT ID C116357


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Aldesleukin + Vactosertib Aldesleukin Vactosertib 0 1
Durvalumab + Vactosertib Durvalumab Vactosertib 0 1
Imatinib + Vactosertib Imatinib Vactosertib 0 0
Paclitaxel + Vactosertib Paclitaxel Vactosertib 0 0
Pomalidomide + Vactosertib Pomalidomide Vactosertib 0 1
Vactosertib Vactosertib 0 4
Vactosertib + VAY736 VAY736 Vactosertib 0 0

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