Drug Detail


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Drug Name PLX8394
Trade Name
Synonyms PLX 8394|PLX-8394|FORE8394|FORE-8394|FORE 8394
Drug Descriptions

PLX8394 is a RAF inhibitor that inhibits wild-type and mutant BRAF, as well as CRAF, and does not paradoxically activate MAPK signaling, potentially resulting in decreased proliferation of BRAF-mutant tumor cells (PMID: 26466569, PMID: 24283590, PMID: 28659148, PMID: 30559419).

DrugClasses BRAF Inhibitor 25 CRAF Inhibitor 12
CAS Registry Number 1393466-87-9
NCIT ID C113330


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cetuximab + PLX8394 Cetuximab PLX8394 2 0
Cobicistat + PLX8394 Cobicistat PLX8394 0 1
Everolimus + PLX8394 Everolimus PLX8394 0 0
JQ1 + PLX8394 JQ1 PLX8394 1 0
PLX8394 PLX8394 25 3

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