Drug Detail


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Drug Name Cobicistat
Trade Name Tybost
Synonyms GS 9350|Evotaz|Genvoya|Prezcobix|Rezolsta|Stribild
Drug Descriptions

Tybost (cobicistat) is an inhibitor of human cytochrome P450 3A (CYP3A), which potentially enhances exposure to other co-administered drugs (PMID: 24900196, PMID: 35933915). Tybost (cobicistat) is FDA approved to increase systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection (FDA.gov).

CAS Registry Number 1004316-88-4
NCIT ID C97360


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cobicistat Cobicistat 0 0
Cobicistat + Gemcitabine + Nab-paclitaxel Cobicistat Gemcitabine Nab-paclitaxel 0 1
Cobicistat + Olaparib Cobicistat Olaparib 0 1
Cobicistat + Osimertinib Cobicistat Osimertinib 0 0
Cobicistat + PLX8394 Cobicistat PLX8394 0 1

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