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|Therapy Name||Binimetinib + Panitumumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Binimetinib||Mektovi||ARRY-162|ARRY-438162|MEK162||MEK inhibitor (Pan) 22 MEK1 Inhibitor 20 MEK2 Inhibitor 18||Mektovi (binimetinib) inhibits MEK1 and MEK2 resulting in inhibition of growth factor-mediated signaling and decreased tumor cell proliferation (PMID: 23587417). Mektovi (binimetinib) in combination with Braftovi (encorafenib) is FDA approved for use in patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation (FDA.gov).|
|Panitumumab||Vectibix||ABX-EGF||EGFR Antibody 30||Vectibix (panitumumab) is a monoclonal antibody directed against EGFR, which inhibits cell proliferation and induces apoptosis (PMID: 18998757). Vectibix (panitumumab) is FDA approved for metastatic colorectal cancer patients with wild-type KRAS and NRAS (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF K601E MAP2K1 V211D||colon cancer||predicted - resistant||Binimetinib + Panitumumab||Case Reports/Case Series||Actionable||In a clinical case study, a patient with metastatic colon cancer harboring BRAF K601E developed progressive disease after 6 weeks of Mektovi (binimetinib) and Vectibix (panitumumab) combination treatment, MAP2K1 V211D was identified as a co-occuring mutation in the biopsy from the new metastasis site (PMID: 31227518).||31227518|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|