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Drug Name Onvansertib
Trade Name
Synonyms PCM-075|PCM 075|NMS-P937
Drug Descriptions

Onvansertib (PCM-075) is an ATP-competitive inhibitor of PLK1, resulting in cell cycle arrest and apoptosis in cancer cells (J Clin Oncol 36, 2018 (suppl 6S; abstr 369), PMID: 32017934, PMID: 32183025).

DrugClasses PLK1 Inhibitor 16

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Onvansertib Abiraterone Onvansertib 1 0
Abiraterone + Onvansertib + Prednisone Abiraterone Onvansertib Prednisone 0 1
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Onvansertib Bevacizumab Fluorouracil Irinotecan Leucovorin Onvansertib 0 1
Cytarabine + Decitabine + Onvansertib Cytarabine Decitabine Onvansertib 0 1
Cytarabine + Onvansertib Cytarabine Onvansertib 1 1
Decitabine + Onvansertib Decitabine Onvansertib 1 1
Eribulin + Onvansertib Eribulin Onvansertib 1 0
Onvansertib Onvansertib 3 0
Onvansertib + Paclitaxel Onvansertib Paclitaxel 1 0


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