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Drug Name Onvansertib
Trade Name
Synonyms PCM-075|PCM 075|NMS-P937
Drug Descriptions

Onvansertib (PCM-075) is an ATP-competitive inhibitor of PLK1, which may result in cell cycle arrest, apoptosis, reduced tumor cell proliferation and colony formation in culture, and decreased tumor formation in mouse models (PMID: 22319201, PMID: 32017934, PMID: 32183025).

DrugClasses PLK1 Inhibitor 16
CAS Registry Number 1034616-18-6
NCIT ID C143162

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Onvansertib Abiraterone Onvansertib 0 0
Abiraterone + Onvansertib + Prednisone Abiraterone Onvansertib Prednisone 0 1
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Onvansertib Bevacizumab Fluorouracil Irinotecan Leucovorin Onvansertib 0 1
Cytarabine + Decitabine + Onvansertib Cytarabine Decitabine Onvansertib 0 1
Cytarabine + Onvansertib Cytarabine Onvansertib 0 1
Decitabine + Onvansertib Decitabine Onvansertib 0 1
Eribulin + Onvansertib Eribulin Onvansertib 0 0
Fluorouracil + Leucovorin + MM-398 + Onvansertib Fluorouracil Leucovorin MM-398 Onvansertib 0 1
Onvansertib Onvansertib 0 0
Onvansertib + Paclitaxel Onvansertib Paclitaxel 0 0


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