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Therapy Name Decitabine + Onvansertib
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Decitabine Dacogen 5-aza-2-deoxycytidine DNMT inhibitor (Pan) 5 Dacogen (decitabine) is cytidine analog that incorporates into DNA and forms covalent bonds with DNA methyltransferases (DNMTs), resulting in decreased DNMT activity and hypomethylation, and potentially leading to reduced tumor growth (PMID: 28159832, PMID: 25130173). Dacogen (decitabine) is FDA approved for use in patients with myelodysplastic syndromes (FDA.gov).
Onvansertib PCM-075|PCM 075|NMS-P937 PLK1 Inhibitor 16 Onvansertib (PCM-075) is an ATP-competitive inhibitor of PLK1, resulting in cell cycle arrest and apoptosis in cancer cells (J Clin Oncol 36, 2018 (suppl 6S; abstr 369), PMID: 32017934, PMID: 32183025).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown acute myeloid leukemia not applicable Decitabine + Onvansertib Phase I Actionable In a Phase I trial, Onvansertib (PCM-075) and Dacogen (decitabine) combination therapy resulted in complete response in 33.3% (2/6) and complete response with incomplete hematologic remission in 16.7% (1/6) of evaluable patients with relapsed or refractory acute myeloid leukemia (Ann Oncol, 30 (Supplement 5): v435-v448, 2019; NCT03303339). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT03303339 Phase Ib/II Decitabine + Onvansertib Cytarabine + Decitabine + Onvansertib Cytarabine + Onvansertib PCM-075 in Combination With Either Low-dose Cytarabine or Decitabine in Adult Patients With Acute Myeloid Leukemia (AML). Recruiting


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