Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Adavosertib
Trade Name
Synonyms MK-1775|AZD1775|AZ1775
Drug Descriptions

Adavosertib (MK-1775) is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity (PMID: 22084170).

DrugClasses WEE1 Inhibitor 4


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Adavosertib Adavosertib 12 22
Adavosertib + AZD8055 AZD8055 Adavosertib 0 0
Adavosertib + Belinostat Adavosertib Belinostat 0 1
Adavosertib + Carboplatin Adavosertib Carboplatin 2 2
Adavosertib + Carboplatin + Paclitaxel Adavosertib Carboplatin Paclitaxel 1 0
Adavosertib + Cisplatin Adavosertib Cisplatin 1 3
Adavosertib + Cisplatin + Docetaxel Adavosertib Cisplatin Docetaxel 1 0
Adavosertib + Doxorubicin Adavosertib Doxorubicin 0 0
Adavosertib + Durvalumab Adavosertib Durvalumab 0 2
Adavosertib + Everolimus Adavosertib Everolimus 1 0
Adavosertib + Gemcitabine Adavosertib Gemcitabine 1 3
Adavosertib + Gemcitabine + Radiotherapy Adavosertib Gemcitabine Radiotherapy 1 0
Adavosertib + Irinotecan Adavosertib Irinotecan 1 2
Adavosertib + Olaparib Adavosertib Olaparib 1 4
Adavosertib + Paclitaxel Adavosertib Paclitaxel 1 1
Adavosertib + Pegylated liposomal-doxorubicin Adavosertib Pegylated liposomal-doxorubicin 0 1
Adavosertib + PF-00477736 Adavosertib PF-00477736 0 0
Adavosertib + Radiotherapy Adavosertib Radiotherapy 0 0
Adavosertib + Temozolomide Adavosertib Temozolomide 0 1

Additional content available in CKB BOOST