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Drug Name Adavosertib
Trade Name
Synonyms MK-1775|AZD1775|AZ1775
Drug Descriptions

Adavosertib (MK-1775) is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity (PMID: 22084170).

DrugClasses WEE1 Inhibitor 4

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adavosertib Adavosertib 12 22
Adavosertib + AZD8055 AZD8055 Adavosertib 0 0
Adavosertib + Belinostat Adavosertib Belinostat 0 1
Adavosertib + Carboplatin Adavosertib Carboplatin 2 2
Adavosertib + Carboplatin + Paclitaxel Adavosertib Carboplatin Paclitaxel 1 0
Adavosertib + Cisplatin Adavosertib Cisplatin 1 3
Adavosertib + Cisplatin + Docetaxel Adavosertib Cisplatin Docetaxel 1 0
Adavosertib + Doxorubicin Adavosertib Doxorubicin 0 0
Adavosertib + Durvalumab Adavosertib Durvalumab 0 2
Adavosertib + Everolimus Adavosertib Everolimus 1 0
Adavosertib + Gemcitabine Adavosertib Gemcitabine 1 3
Adavosertib + Gemcitabine + Radiotherapy Adavosertib Gemcitabine Radiotherapy 1 0
Adavosertib + Irinotecan Adavosertib Irinotecan 1 2
Adavosertib + Olaparib Adavosertib Olaparib 1 4
Adavosertib + Paclitaxel Adavosertib Paclitaxel 1 1
Adavosertib + Pegylated liposomal-doxorubicin Adavosertib Pegylated liposomal-doxorubicin 0 1
Adavosertib + PF-00477736 Adavosertib PF-00477736 0 0
Adavosertib + Radiotherapy Adavosertib Radiotherapy 0 0
Adavosertib + Temozolomide Adavosertib Temozolomide 0 1


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