Drug Detail


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Drug Name Avapritinib
Trade Name Ayvakit
Synonyms BLU-285
Drug Descriptions

Ayvakit (avapritinib) is a selective inhibitor of PDGFRA D842V and KIT exon 17 mutants, including KIT D816V, potentially resulting in decreased tumor growth (PMID: 30274985). Ayvakit (avapritinib) is FDA approved for use in patients with unresectable or metastatic gastrointestinal stromal tumor harboring a PDGFRA exon 18 mutation, including D842V, and in patients with advanced systemic mastocytosis (FDA.gov).

DrugClasses KIT Inhibitor 55 PDGFR-alpha Inhibitor 10
CAS Registry Number 1703793-34-3
NCIT ID C123827


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adavosertib + Avapritinib Adavosertib Avapritinib 2 0
Avapritinib Avapritinib 65 7
Avapritinib + Midazolam Avapritinib Midazolam 0 1

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