Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name HRX-0233
Trade Name
Synonyms HRX0233|HRX 0233
Drug Descriptions

HRX-0233 is a MAP2K4 inhibitor, which potentially synergizes with MAPK or KRAS inhibitors to decrease tumor growth (PMID: 38377196).

CAS Registry Number NA


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
HRX-0233 HRX-0233 0 0
HRX-0233 + RMC-6236 HRX-0233 RMC-6236 0 0
HRX-0233 + SCH772984 HRX-0233 SCH772984 0 0
HRX-0233 + Sotorasib HRX-0233 Sotorasib 0 0
HRX-0233 + Trametinib HRX-0233 Trametinib 0 0

Additional content available in CKB BOOST