Drug Detail


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Drug Name Lazertinib
Trade Name
Synonyms GNS 1480|YH25448|JNJ-73841937|JNJ73841937|JNJ 73841937|YH 25448|YH-25448
Drug Descriptions

Lazertinib (YH25448) is an irreversible protein kinase inhibitor with selective activity against mutant EGFR, which may lead to growth inhibition of EGFR-mutant tumor cells and reduced toxicity (PMID: 30670498, PMID: 32599977).

DrugClasses EGFR Inhibitor 3rd gen 26
CAS Registry Number 1903008-80-9
NCIT ID C148147


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Amivantamab-vmjw + Bevacizumab + Lazertinib Amivantamab-vmjw Bevacizumab Lazertinib 0 1
Amivantamab-vmjw + Carboplatin + Lazertinib + Pemetrexed Disodium Amivantamab-vmjw Carboplatin Lazertinib Pemetrexed Disodium 0 3
Amivantamab-vmjw + Dexamethasone + Lazertinib Amivantamab-vmjw Dexamethasone Lazertinib 0 1
Amivantamab-vmjw + Lazertinib Amivantamab-vmjw Lazertinib 0 7
Amivantamab-vmjw + Lazertinib + Methotrexate Amivantamab-vmjw Lazertinib Methotrexate 0 1
Amivantamab-vmjw + Lazertinib + Montelukast Amivantamab-vmjw Lazertinib Montelukast 0 1
Amivantamab-vmjw + Lazertinib + rHuPH20 Amivantamab-vmjw Lazertinib rHuPH20 0 1
Lazertinib Lazertinib 0 3
Lazertinib + Selumetinib Lazertinib Selumetinib 0 0
Lazertinib + Trametinib Lazertinib Trametinib 0 0

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