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Drug Name rHuPH20
Trade Name
Synonyms Hylenex
Drug Descriptions

rHuPH20 is recombinant human hyaluronidase lacking the GPI anchor domain, which may enhance dispersion of substances delivered subcutaneously (PMID: 25967925, PMID: 16876899, PMID: 30744432).

CAS Registry Number 757971-58-7
NCIT ID C61504


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Amivantamab-vmjw + Lazertinib + rHuPH20 Amivantamab-vmjw Lazertinib rHuPH20 0 1
Amivantamab-vmjw + rHuPH20 Amivantamab-vmjw rHuPH20 0 1
Atezolizumab + rHuPH20 Atezolizumab rHuPH20 0 2
Daratumumab + Lenalidomide + rHuPH20 Daratumumab Lenalidomide rHuPH20 0 1
Daratumumab + rHuPH20 Daratumumab rHuPH20 0 2
Ipilimumab + Nivolumab + rHuPH20 Ipilimumab Nivolumab rHuPH20 0 1
Nivolumab + Relatlimab + rHuPH20 Nivolumab Relatlimab rHuPH20 0 2
Nivolumab + rHuPH20 Nivolumab rHuPH20 0 2
rHuPH20 rHuPH20 0 0

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