Therapy Detail

Therapy Name AZ-TAK1 + Selumetinib
Synonym
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AZ-TAK1 AZ-TAK1 is an ATP-competitive inhibitor of TAK1, which may result in apoptotic activity and inhibition of cell growth in cancer cells (PMID: 22649101).
Selumetinib AZD6244|ARRY-142886 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 Selumetinib (AZD6244) inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, reducing cellular proliferation in various cancers (PMID: 27467210).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS mutant colon cancer sensitive AZ-TAK1 + Selumetinib Preclinical - Cell culture Actionable In a preclinical study, the combination of AZ-TAK1 and Selumetinib (AZD6244) resulted in an additive effect in colon cancer cells harboring KRAS mutant in culture, demonstrating a 90% growth reduction (PMID: 27655129). 27655129
Clinical Trial Phase Therapies Title Recruitment Status