Drug Detail


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Drug Name RAF265
Trade Name
Synonyms CHIR-265|NVP-RAF265
Drug Descriptions

RAF265 inhibits the activities of several intracellular kinases, including BRAF(V600E), BRAF(wild type), c-RAF (RAF1), VEGF receptor 2 (VEGFR2/KDR), platelet-derived growth factor receptor (PDGFR), colony-stimulating factor (CSF)1R, RET and c-KIT, SRC, STE20, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death (PMID: 22351689, PMID: 28719152).

DrugClasses BRAF Inhibitor 21 CRAF Inhibitor 11 VEGFR2 Inhibitor 35
CAS Registry Number 927880-90-8
NCIT ID C61311


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cisplatin + RAF265 Cisplatin RAF265 0 0
RAF265 RAF265 10 0
RAF265 + Selumetinib RAF265 Selumetinib 0 0
RAF265 + Trametinib RAF265 Trametinib 3 0

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