Drug Detail


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Drug Name Cixutumumab
Trade Name
Synonyms IMC-A12
Drug Descriptions

Cixutumumab (IMC-A12) is an antibody against membrane-bound IGF-1R that prevents IGF-1 binding, inhibiting PI3K/AKT pathway activation and potentially leading to decreased tumor cell proliferation and increased tumor cell death (PMID: 29520435, PMID: 29909907).

DrugClasses IGF1R Antibody 8
CAS Registry Number 947687-12-9
NCIT ID C79828


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Carboplatin + Cixutumumab + Paclitaxel Bevacizumab Carboplatin Cixutumumab Paclitaxel 0 0
Cetuximab + Cixutumumab Cetuximab Cixutumumab 0 0
Cixutumumab Cixutumumab 0 2
Cixutumumab + Everolimus + Octreotide acetate Cixutumumab Everolimus Octreotide acetate 0 0

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