Therapy Detail

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Therapy Name Cixutumumab
Synonyms
Therapy Description

Cixutumumab is an antibody against membrane-bound IGF-1R that prevents IGF-1 binding, inhibiting PI3K/AKT pathway activation and potentially leading to decreased tumor cell proliferation and increased tumor cell death (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cixutumumab IMC-A12 IGF1R Antibody 8 Cixutumumab (IMC-A12) is an antibody against membrane-bound IGF-1R that prevents IGF-1 binding, inhibiting PI3K/AKT pathway activation and potentially leading to decreased tumor cell proliferation and increased tumor cell death (PMID: 29520435, PMID: 29909907).

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown head and neck squamous cell carcinoma no benefit Cixutumumab Phase II Actionable In a Phase II trial, Cixutumumab (IMC-A12) treatment resulted in a median progression-free survival (PFS) of 1.9 months, a 6-month PFS rate of 6%, an objective response rate of 2%, a clinical benefit rate of 19% (n=47; 1 complete response, 8 stable disease), and a median overall survival (OS) of 5.3 months in metastatic head and neck squamous cell carcinoma patients, and did not result in an improved PFS or OS compared to historical Erbitux (cetuximab) treatment alone (PMID: 29909907). 29909907

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  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00957853 Phase II Cetuximab Cixutumumab Preoperative Treatment With Cetuximab and/or IMC-A12 Completed USA 0
NCT01263782 Phase II Bevacizumab Carboplatin + Pemetrexed Disodium Cixutumumab BATTLE-FL: Front-Line Biomarker-Integrated Treatment Study in Non Small Cell Lung Cancer Completed USA 0


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