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DFF332 inhibits HIF-2alpha and blocks its DNA binding, which may lead to downregulation of HIF-2alpha target genes involved in tumor cell growth and survival (NCI Drug Dictionary).
|DrugClasses||HIF2A Inhibitor 5|
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|DFF332 + Everolimus||DFF332 Everolimus||0||1|
|DFF332 + PBF-509 + Spartalizumab||DFF332 PBF-509 Spartalizumab||0||1|