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Drug Name PBF-509
Trade Name
Synonyms Taminadenant|NIR178
Drug Descriptions

Taminadenant (PBF-509) binds to and inhibits the adenosine A2A (ADORA2A) receptor on immune cells, resulting in activation of an anti-tumor immune response by blocking binding of the immunosuppressive metabolite, adenosine (PMID: 29758241, PMID: 28582704).

DrugClasses Adenosine Targeting 20
CAS Registry Number 1337962-47-6
NCIT ID C121664


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Therapy Name Drugs Efficacy Evidence Clinical Trials
DFF332 + PBF-509 + Spartalizumab DFF332 PBF-509 Spartalizumab 0 1
Ieramilimab + PBF-509 + Spartalizumab Ieramilimab PBF-509 Spartalizumab 0 1
KAZ954 + PBF-509 KAZ954 PBF-509 0 1
NZV930 + PBF-509 NZV930 PBF-509 0 1
NZV930 + PBF-509 + Spartalizumab NZV930 PBF-509 Spartalizumab 0 1
PBF-509 PBF-509 0 1
PBF-509 + Spartalizumab PBF-509 Spartalizumab 0 2

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