Drug Detail


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Drug Name Taminadenant
Trade Name
Synonyms NIR178|PBF-509
Drug Descriptions

Taminadenant binds to and inhibits the adenosine A2A (ADORA2A) receptor on immune cells, resulting in activation of an anti-tumor immune response by blocking binding of the immunosuppressive metabolite, adenosine (PMID: 29758241, PMID: 28582704).

DrugClasses Adenosine Targeting 23
CAS Registry Number 1337962-47-6
NCIT ID C121664


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Therapy Name Drugs Efficacy Evidence Clinical Trials
DFF332 + Spartalizumab + Taminadenant DFF332 Spartalizumab Taminadenant 0 1
Ieramilimab + Spartalizumab + Taminadenant Ieramilimab Spartalizumab Taminadenant 0 1
KAZ954 + Taminadenant KAZ954 Taminadenant 0 1
NZV930 + Spartalizumab + Taminadenant NZV930 Spartalizumab Taminadenant 0 1
NZV930 + Taminadenant NZV930 Taminadenant 0 1
Spartalizumab + Taminadenant Spartalizumab Taminadenant 0 2
Taminadenant Taminadenant 0 1

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