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|Therapy Name||LAG525 + PBF-509 + Spartalizumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|LAG525||LAG-525|Leramilimab||Immune Checkpoint Inhibitor 98 LAG3 Antibody 12||LAG525 (Leramilimab) is a monoclonal antibody that targets LAG3 and blocks interaction with MHC class II molecules, leading to enhanced T-cell response to tumor cells and decreased tumor growth (NCI Drug Dictionary).|
|PBF-509||Taminadenant|NIR178||Adenosine Targeting 16||Taminadenant (PBF-509) binds to and inhibits the adenosine A2A (ADORA2A) receptor on immune cells, resulting in activation of an anti-tumor immune response by blocking binding of the immunosuppressive metabolite, adenosine (PMID: 29758241, PMID: 28582704).|
|Spartalizumab||PDR001|PDR-001||Immune Checkpoint Inhibitor 98 PD-L1/PD-1 antibody 68||Spartalizumab (PDR001) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 32364844, PMID: 32179633).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03742349||Phase I||Canakinumab + LAG525 + Spartalizumab LAG525 + MCS110 + Spartalizumab Capmatinib + LAG525 + Spartalizumab LAG525 + PBF-509 + Spartalizumab||Study of Safety and Efficacy of Novel Immunotherapy Combinations in Patients With Triple Negative Breast Cancer (TNBC).||Recruiting||USA||8|