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Fosbretabulin is metabolized to combretastatin A4, which binds to tubulin dimers, preventing microtubule polymerization. This causes mitotic arrest and apoptosis in endothelial cells, leading to collapse of tumor blood cells, disrupting blood flow to the tumor and possibly causing tumor necrosis (PMID: 31932108).
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Bevacizumab + Fosbretabulin||Bevacizumab Fosbretabulin||0||1|
|Everolimus + Fosbretabulin||Everolimus Fosbretabulin||0||1|