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|Therapy Name||Everolimus + Fosbretabulin|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Everolimus||Afinitor||RAD001|Zortress||mTORC1 Inhibitor 9||Afinitor (everolimus) binds to FKBP-12 and allosterically inhibits mTOR, leading to decreased mTORC1 signaling and potentially resulting in decreased tumor cell growth (PMID: 17766661, PMID: 28400999). Afinitor (everolimus) is FDA approved for use in neuroendocrine tumors of pancreatic, lung or gastrointestinal tract origin, advanced renal cell carcinoma, in adult and pediatric patients aged 1 year and older with tuberous sclerosis complex who have subependymal giant cell astrocytoma, and in combination with Aromasin (exemestane) in hormone receptor-positive, HER2-negative breast cancer (FDA.gov).|
|Fosbretabulin||Fosbretabulin is metabolized to combretastatin A4, which binds to tubulin dimers, preventing microtubule polymerization. This causes mitotic arrest and apoptosis in endothelial cells, leading to collapse of tumor blood cells, disrupting blood flow to the tumor and possibly causing tumor necrosis (PMID: 31932108).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03014297||Phase I||Everolimus + Fosbretabulin||Fosbretabulin With Everolimus in Neuroendocrine Tumors With Progression||Terminated||USA||0|