Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Xentuzumab
Trade Name
Synonyms BI 836845
Drug Descriptions

Xentuzumab (BI 836845) is a monoclonal antibody that binds to IGF-1 and IGF-2 and prevents binding to the IGF receptor (IGF-1R), resulting in decreased IGF-1R signaling (PMID: 32161368, PMID: 32054790).

DrugClasses IGF1/2 Antibody 2
CAS Registry Number 1417158-65-6
NCIT ID C106118


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Anastrozole + Xentuzumab Abemaciclib Anastrozole Xentuzumab 0 1
Abemaciclib + Fulvestrant + Xentuzumab Abemaciclib Fulvestrant Xentuzumab 0 1
Abemaciclib + Letrozole + Xentuzumab Abemaciclib Letrozole Xentuzumab 0 1
Abemaciclib + Xentuzumab Abemaciclib Xentuzumab 0 1
Everolimus + Exemestane + Xentuzumab Everolimus Exemestane Xentuzumab 0 1
PHA-665752 + Xentuzumab PHA-665752 Xentuzumab 0 0
Xentuzumab Xentuzumab 0 2

Additional content available in CKB BOOST