Drug Detail


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Drug Name Xentuzumab
Trade Name
Synonyms BI 836845
Drug Descriptions

Xentuzumab (BI 836845) is a monoclonal antibody that binds to IGF-1 and IGF-2 and prevents binding to the IGF receptor (IGF-1R), resulting in decreased IGF-1R signaling (PMID: 32161368, PMID: 32054790).

DrugClasses IGF1/2 Antibody 2
CAS Registry Number 1417158-65-6
NCIT ID C106118


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Anastrozole + Xentuzumab Abemaciclib Anastrozole Xentuzumab 0 1
Abemaciclib + Fulvestrant + Xentuzumab Abemaciclib Fulvestrant Xentuzumab 0 1
Abemaciclib + Letrozole + Xentuzumab Abemaciclib Letrozole Xentuzumab 0 1
Abemaciclib + Xentuzumab Abemaciclib Xentuzumab 0 1
Cisplatin + Xentuzumab Cisplatin Xentuzumab 0 0
Everolimus + Exemestane + Xentuzumab Everolimus Exemestane Xentuzumab 0 1
PHA-665752 + Xentuzumab PHA-665752 Xentuzumab 0 0
Xentuzumab Xentuzumab 0 2

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