Drug Detail


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Drug Name RXDX-105
Trade Name
Synonyms AC013773|CEP-32496|Agerafenib
Drug Descriptions

Agerafenib (RXDX-105) inhibits wild-type BRAF, BRAF V600E, c-RAF, ABL1 (and BCR-ABL), c-KIT, RET, PDGFR beta, and VEGFR2, potentially resulting in decreased tumor growth (PMID: 22319199, PMID: 31695841).

DrugClasses ABL Inhibitor (pan) 9 ABL1 Inhibitor 8 BCR-ABL Inhibitor 32 BRAF Inhibitor 25 CRAF Inhibitor 12 KIT Inhibitor 57 PDGFR-beta Inhibitor 14 RET Inhibitor 52 VEGFR2 Inhibitor 37
CAS Registry Number 1188910-76-0
NCIT ID C107245


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Crizotinib + RXDX-105 Crizotinib RXDX-105 0 0
GSK2126458 + RXDX-105 GSK2126458 RXDX-105 1 0
RXDX-105 RXDX-105 7 3
RXDX-105 + Trametinib RXDX-105 Trametinib 1 0
RXDX-105 + Volasertib RXDX-105 Volasertib 0 0

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