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Drug Name Arsenic trioxide
Trade Name Trisenox
Synonyms ATO
Drug Descriptions

Trisenox (arsenic trioxide) has multiple mechanisms of action, including inhibition of Gli1 and Gli2 transcription factors (PMID: 26891329). Trisenox (arsenic trioxide) is FDA approved for patients with acute promyelocytic leukemia with PML-RARA translocations (FDA.gov).

DrugClasses GLI1/2 inhibitor 6

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Arsenic trioxide Arsenic trioxide 1 4
Arsenic trioxide + Chloroquine + JQ1 Arsenic trioxide Chloroquine JQ1 1 0
Arsenic trioxide + Cytarabine + Methotrexate + Tretinoin Arsenic trioxide Cytarabine Methotrexate Tretinoin 1 0
Arsenic trioxide + Decitabine Arsenic trioxide Decitabine 0 1
Arsenic trioxide + Gemtuzumab ozogamicin + Tretinoin Arsenic trioxide Gemtuzumab ozogamicin Tretinoin 0 2
Arsenic trioxide + Itraconazole Arsenic trioxide Itraconazole 0 1
Arsenic trioxide + JQ1 Arsenic trioxide JQ1 1 0
Arsenic trioxide + Posaconazole Arsenic trioxide Posaconazole 5 0
Arsenic trioxide + Tretinoin Arsenic trioxide Tretinoin 1 0


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