Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name TEN-010
Trade Name
Synonyms RG-6146|JQ2|RO6870810|RG6146|RO-6870810
Drug Descriptions

RO6870810 (TEN-010) binds to the bromodomain of BET proteins preventing their interaction with acetylated histone peptides, thus disrupting chromatin remodeling, gene expression, and cell proliferation (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A49).

DrugClasses BET Inhibitor (Pan) 32
CAS Registry Number 1349719-98-7
NCIT ID C112500

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + TEN-010 Atezolizumab TEN-010 0 1
Daratumumab + TEN-010 Daratumumab TEN-010 0 1
Rituximab + TEN-010 + Venetoclax Rituximab TEN-010 Venetoclax 0 1
TEN-010 TEN-010 0 3


Additional content available in CKB BOOST