Drug Detail


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Drug Name TEN-010
Trade Name
Synonyms RG-6146|JQ2|RO6870810|RG6146|RO-6870810
Drug Descriptions

RO6870810 (TEN-010) binds to the bromodomain of BET proteins preventing their interaction with acetylated histone peptides, thus disrupting chromatin remodeling, gene expression, and cell proliferation (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A49).

DrugClasses BET Inhibitor (Pan) 32
CAS Registry Number 1349719-98-7
NCIT ID C112500


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + TEN-010 Atezolizumab TEN-010 0 1
Daratumumab + TEN-010 Daratumumab TEN-010 0 1
Rituximab + TEN-010 + Venetoclax Rituximab TEN-010 Venetoclax 0 1
TEN-010 TEN-010 0 3

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