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Drug Name Ciltacabtagene autoleucel
Trade Name Carvykti
Synonyms JNJ-68284528|JNJ-4528|Cilta-cel
Drug Descriptions

Carvykti (ciltacabtagene autoleucel) is a chimeric antigen receptor T (CAR T)-cell therapy targeting B-cell maturation antigen (BCMA) that may induce cytotoxic immune response against BCMA-expressing tumor cells (PMID: 31622496, PMID: 34175021). Carvykti (ciltacabtagene autoleucel) is FDA approved for use in adult patients with relapsed or refractory multiple myeloma after four or more prior lines of therapy (FDA.gov).

DrugClasses
CAS Registry Number NA
NCIT ID C148498

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + Ciltacabtagene autoleucel + Cyclophosphamide + Dexamethasone + Fludarabine + Pomalidomide Bortezomib Ciltacabtagene autoleucel Cyclophosphamide Dexamethasone Fludarabine Pomalidomide 0 1
Ciltacabtagene autoleucel Ciltacabtagene autoleucel 0 4
Ciltacabtagene autoleucel + Cyclophosphamide + Daratumumab + Dexamethasone + Fludarabine + Pomalidomide Ciltacabtagene autoleucel Cyclophosphamide Daratumumab Dexamethasone Fludarabine Pomalidomide 0 1
Ciltacabtagene autoleucel + Cyclophosphamide + Fludarabine Ciltacabtagene autoleucel Cyclophosphamide Fludarabine 0 2


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