Drug Detail


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Drug Name INCB001158
Trade Name
Synonyms CB-1158|CB1158|CB 1158
Drug Descriptions

INCB001158 (CB-1158) is a human arginase inhibitor that restores arginine levels in T-cells, thereby promoting T-cell proliferation and anti-tumor immunity (PMID: 32647818).

CAS Registry Number 2095732-06-0
NCIT ID C142866


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cisplatin + Gemcitabine + INCB001158 Cisplatin Gemcitabine INCB001158 0 1
Daratumumab + INCB001158 Daratumumab INCB001158 0 1
Epacadostat + INCB001158 Epacadostat INCB001158 0 1
Epacadostat + INCB001158 + Pembrolizumab Epacadostat INCB001158 Pembrolizumab 0 1
Fluorouracil + INCB001158 + Leucovorin + Oxaliplatin Fluorouracil INCB001158 Leucovorin Oxaliplatin 0 1
INCB001158 INCB001158 0 1
INCB001158 + Nivolumab INCB001158 Nivolumab 0 1
INCB001158 + Paclitaxel INCB001158 Paclitaxel 0 1

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