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Therapy Name Iberdomide
Synonyms
Therapy Description

Iberdomide (CC-220) binds to the ubiquitin E3 ligase complex member Cereblon (CRBN), which may lead to increased ubiquitination and degradation of transcription factors, resulting in decreased B-cell proliferation (PMID: 29945920, PMID: 28848067, PMID: 31719682).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Iberdomide CC220|CC-220|CC 220 Iberdomide (CC-220) binds to the ubiquitin E3 ligase complex member Cereblon (CRBN), which may lead to increased ubiquitination and degradation of transcription factors, resulting in decreased B-cell proliferation (PMID: 29945920, PMID: 28848067, PMID: 31719682).

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05354557 Phase II Iberdomide Study of Iberdomide in People With Multiple Myeloma Who Have Had an Autologous Hematopoietic Stem Cell Transplant (AHCT) Recruiting USA 0
NCT05896228 Phase II Iberdomide Carfilzomib + Daratumumab + Dexamethasone + Iberdomide Iberdomide, Daratumumab, Carfilzomib, and Dexamethasone (Iber-KDd) in Patients With Relapsed/Refractory Multiple Myeloma (Iber-KDd) Recruiting USA 0
NCT05827016 Phase III Lenalidomide Iberdomide A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma Recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS 24
NCT05177536 Phase II Iberdomide Iberdomide Maintenance Therapy in Patients With Multiple Myeloma Recruiting USA 0
NCT06216158 Phase III Iberdomide Iberdomide + Isatuximab Dexamethasone Iberdomide vs. Iberdomide Plus Isatuximab Maintenance Therapy Post ASCT in Newly Diagnosed Multiple Myeloma Not yet recruiting DEU 0
NCT04564703 Phase II Iberdomide Iberdomide (Cc220) Maintenance After Asct in Newly Diagnosed MM Patients Active, not recruiting NLD | ITA | FRA 1
NCT04776395 Phase II Iberdomide Dexamethasone + Iberdomide Iberdomide Alone or in Combination With Dexamethasone for the Treatment of Intermediate- or High-Risk Smoldering Multiple Myeloma Recruiting USA 0
NCT04464798 Phase I Iberdomide Iberdomide + Obinutuzumab Iberdomide + Rituximab A Dose Finding and Safety Study of CC-220, Alone and in Combination With an Anti-CD20 Monoclonal Antibody (mAb) in Subjects With Relapsed or Refractory Lymphomas Active, not recruiting USA | ITA | FRA | DEU 2
NCT02773030 Phase Ib/II Iberdomide Dexamethasone + Iberdomide Daratumumab + Dexamethasone + Iberdomide Bortezomib + Dexamethasone + Iberdomide A Study to Determine Dose and Tolerability of CC-220 Monotherapy, in Combination With Dexamethasone, and in Combination With Dexamethasone and Daratumumab or Bortezomib in Subjects With Relapsed and Refractory Multiple Myeloma (MM) Active, not recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | AUS 2


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