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Nirogacestat (PF-03084014) is a small molecule that selectively binds and inhibits Gamma-secretase inhibiting its proteolytic activity on downstream targets including NOTCH receptor proteins thus blocking pathway activation in cancer (PMID: 28887726, PMID: 31211955).
|DrugClasses||Gamma secretase inhibitor 12|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Docetaxel + PF-03084014||Docetaxel PF-03084014||1||1|