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Drug Name Nirogacestat
Trade Name Ogsiveo
Synonyms PF-03084014|PF 03084014|PF03084014
Drug Descriptions

Ogsiveo (nirogacestat) is a small molecule that selectively binds to Gamma-secretase and inhibits its proteolytic activity on downstream targets including NOTCH receptor proteins, thus blocking NOTCH pathway activation in cancer (PMID: 28887726, PMID: 31211955). Ogsiveo (nirogacestat) is FDA-approved for use in patients with progressing desmoid tumors (FDA.gov).

DrugClasses Gamma secretase inhibitor 13
CAS Registry Number 1290543-63-3
NCIT ID C82383

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABBV-383 + Nirogacestat ABBV-383 Nirogacestat 0 1
belantamab mafodotin-blmf + Nirogacestat Nirogacestat belantamab mafodotin-blmf 0 2
Celecoxib + Nirogacestat Celecoxib Nirogacestat 1 0
Cyclophosphamide + Fludarabine + Nirogacestat + PBCAR269A Cyclophosphamide Fludarabine Nirogacestat PBCAR269A 0 1
Docetaxel + Nirogacestat Docetaxel Nirogacestat 0 1
Elranatamab-bcmm + Nirogacestat Elranatamab-bcmm Nirogacestat 0 1
Nirogacestat Nirogacestat 3 10
Nirogacestat + Teclistamab Nirogacestat Teclistamab 0 1


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