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|Therapy Name||Nirogacestat + Teclistamab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Nirogacestat||PF-03084014|PF 03084014|PF03084014||Gamma secretase inhibitor 13||Nirogacestat (PF-03084014) is a small molecule that selectively binds to Gamma-secretase and inhibits its proteolytic activity on downstream targets including NOTCH receptor proteins, thus blocking NOTCH pathway activation in cancer (PMID: 28887726, PMID: 31211955).|
|Teclistamab||Tecvayli||JNJ-64007957|BCMAxCD3|JNJ 64007957|JNJ64007957||CD3 Antibody 78 TNFRSF17 Antibody 14||Tecvayli (teclistamab) is a bispecific antibody that targets CD3 and BCMA, potentially resulting in increased immune response against BCMA-expressing tumor cells (Blood Dec 2016, 128 (22) 5668). Tecvayli (teclistamab) is FDA approved for use in adult patients with relapsed or refractory multiple myeloma who have received four or more prior lines of therapy (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04722146||Phase I||Nirogacestat + Teclistamab Daratumumab + Pomalidomide + Teclistamab Bortezomib + Daratumumab + Lenalidomide + Teclistamab||A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma||Active, not recruiting||USA | GBR | FRA | BEL | AUS||0|