Drug Detail


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Drug Name Afuresertib
Trade Name
Synonyms GSK2110183|GSK-2110183
Drug Descriptions

Afuresertib (GSK2110183) is a pan-AKT, ATP-competitive inhibitor, which may result in inhibition of the PI3K/AKT signaling pathway and tumor cell proliferation, and induction of tumor cell apoptosis (PMID: 25075128, PMID: 30563934).

DrugClasses Akt Inhibitor (Pan) 21 AKT Inhibitor (Pan) - ATP competitive 7
CAS Registry Number 1047644-62-1
NCIT ID C82390


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afuresertib Afuresertib 1 3
Afuresertib + Carboplatin + Paclitaxel Afuresertib Carboplatin Paclitaxel 0 0
Afuresertib + Carfilzomib Afuresertib Carfilzomib 0 1
Afuresertib + Fulvestrant Afuresertib Fulvestrant 0 1
Afuresertib + LAE001 + Prednisone Afuresertib LAE001 Prednisone 0 1
Afuresertib + Ofatumumab Afuresertib Ofatumumab 0 1
Afuresertib + Paclitaxel Afuresertib Paclitaxel 0 1
Afuresertib + Trametinib Afuresertib Trametinib 0 0

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