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Drug Name Tinostamustine
Trade Name
Synonyms EDO-S101|EDOS101|EDO S101
Drug Descriptions

Tinostamustine (EDO-S101) comprises the structure of the DNA alkylating drug bendumustine combined with the pan-HDAC inhibitor vorinostat, which may both induce DNA damage and inhibit DNA repair resulting in increased tumor cell death (PMID: 28753594, PMID: 32099034, PMID: 31372848).

DrugClasses Chemotherapy - Alkylating 18 HDAC Inhibitor 45
CAS Registry Number 1236199-60-2
NCIT ID C126105

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + Tinostamustine Bortezomib Tinostamustine 0 0
Carfilzomib + Tinostamustine Carfilzomib Tinostamustine 0 0
Delanzomib + Tinostamustine Delanzomib Tinostamustine 0 0
Marizomib + Tinostamustine Marizomib Tinostamustine 0 0
Tinostamustine Tinostamustine 0 5


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