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Drug Name Tinostamustine
Trade Name
Synonyms EDO-S101|EDOS101|EDO S101
Drug Descriptions

Tinostamustine (EDO-S101) comprises the structure of the DNA alkylating drug bendumustine combined with the pan-HDAC inhibitor vorinostat, which may both induce DNA damage and inhibit DNA repair resulting in increased tumor cell death (PMID: 28753594, PMID: 32099034, PMID: 31372848).

DrugClasses Chemotherapy - Alkylating 14 HDAC Inhibitor 38

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + Tinostamustine Bortezomib Tinostamustine 7 0
Carfilzomib + Tinostamustine Carfilzomib Tinostamustine 7 0
Delanzomib + Tinostamustine Delanzomib Tinostamustine 1 0
Marizomib + Tinostamustine Marizomib Tinostamustine 0 0
Tinostamustine Tinostamustine 1 4


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