Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Tinostamustine
Trade Name
Synonyms EDO-S101|EDOS101|EDO S101
Drug Descriptions

Tinostamustine (EDO-S101) comprises the structure of the DNA alkylating drug bendumustine combined with the pan-HDAC inhibitor vorinostat, which may both induce DNA damage and inhibit DNA repair resulting in increased tumor cell death (PMID: 28753594, PMID: 32099034, PMID: 31372848).

DrugClasses Chemotherapy - Alkylating 18 HDAC Inhibitor 45
CAS Registry Number 1236199-60-2
NCIT ID C126105


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + Tinostamustine Bortezomib Tinostamustine 0 0
Carfilzomib + Tinostamustine Carfilzomib Tinostamustine 0 0
Delanzomib + Tinostamustine Delanzomib Tinostamustine 0 0
Marizomib + Tinostamustine Marizomib Tinostamustine 0 0
Tinostamustine Tinostamustine 0 5

Additional content available in CKB BOOST