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|Therapy Name||Carfilzomib + DT204|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Carfilzomib||Kyprolis||PR-171||Kyprolis (carfilzomib) binds to the 20S proteasome and inhibits its protein degradation activity, thereby leading to the accumulation of ubiquinated proteins, which may result in apoptosis and growth arrest in tumor cells (PMID: 26893241). Kyprolis (carfilzomib) in combination with lenalidomide and dexamethasone, or in combination with Darzalex Faspro (Daratumumab and hyaluronidase-fihj) and dexamethasone is FDA-approved for use in patients with multiple myeloma (FDA.gov).|
|DT204||DT204 is a SCF/SKP2 inhibitor that targets the ubiquitin/proteasome system, specifically inhibiting SKP1, CUL1, and COMMD1, which may result in restored sensitivity to proteasome inhibitors or overcome proteasome inhibitor resistance (PMID: 27677741).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|