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Drug Name Zotiraciclib
Trade Name
Synonyms SB1317|TG02
Drug Descriptions

Zotiraciclib (TG02) is a pyrimidine-based molecule that inhibits CDK1, CDK2, CDK3, CDK5, CDK7, CDK9, JAK2, and FLT3, which results in growth inhibition in tumor cells (PMID: 21860433).

DrugClasses CDK1 Inhibitor 13 CDK2 Inhibitor 19 CDK5 Inhibitor 7 CDK7 Inhibitor 13 CDK9 Inhibitor 16 FLT3 Inhibitor 54 JAK2 Inhibitor 17

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carfilzomib + Zotiraciclib Carfilzomib Zotiraciclib 1 0
Temozolomide + Zotiraciclib Temozolomide Zotiraciclib 0 1
Zotiraciclib Zotiraciclib 3 1


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