Drug Detail


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Drug Name Zotiraciclib
Trade Name
Synonyms SB1317|TG02
Drug Descriptions

Zotiraciclib (TG02) is a pyrimidine-based molecule that inhibits CDK1, CDK2, CDK3, CDK5, CDK7, CDK9, JAK2, and FLT3, which results in growth inhibition in tumor cells (PMID: 21860433).

DrugClasses CDK1 Inhibitor 13 CDK2 Inhibitor 23 CDK5 Inhibitor 8 CDK7 Inhibitor 14 CDK9 Inhibitor 19 FLT3 Inhibitor 60 JAK2 Inhibitor 16
CAS Registry Number 937270-47-8
NCIT ID C105851


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carfilzomib + Zotiraciclib Carfilzomib Zotiraciclib 0 0
Radiotherapy + Zotiraciclib Radiotherapy Zotiraciclib 0 1
Temozolomide + Zotiraciclib Temozolomide Zotiraciclib 0 2
Zotiraciclib Zotiraciclib 1 2

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