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Drug Name Aflibercept
Trade Name Zaltrap
Synonyms AVE 0005|Eylea|Ziv-Aflibercept
Drug Descriptions

Zaltrap (aflibercept) is comprised of human IgG fused to the extracellular domains of VEGFR1 and VEGFR2, which binds VEGF to inhibit tumor angiogenesis and metastasis. Zaltrap (aflibercept) is FDA approved in patients with metastatic colorectal cancer (FDA.gov).

DrugClasses VEGF Antibody 11 VEGFR Inhibitor (Pan) 36
CAS Registry Number 862111-32-8


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Aflibercept Aflibercept 0 9
Aflibercept + Capecitabine Aflibercept Capecitabine 0 1
Aflibercept + Cemiplimab Aflibercept Cemiplimab 0 1
Aflibercept + Docetaxel Aflibercept Docetaxel 0 0
Aflibercept + Fluorouracil + Irinotecan + Leucovorin Aflibercept Fluorouracil Irinotecan Leucovorin 0 4
Aflibercept + Fluorouracil + Leucovorin Aflibercept Fluorouracil Leucovorin 0 4
Aflibercept + Fluorouracil + Leucovorin + Oxaliplatin Aflibercept Fluorouracil Leucovorin Oxaliplatin 0 2
Aflibercept + Ganetespib Aflibercept Ganetespib 0 1
Aflibercept + Pembrolizumab Aflibercept Pembrolizumab 0 1
Aflibercept + Sapanisertib Aflibercept Sapanisertib 0 1

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