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THIO (6-thio-2'-deoxyguanosine) is precursor nucleoside analogue that incorporates into newly synthesized telomeres, leading to telomere dysfunction and apoptosis in telomerase-positive cells, and potential anti-tumor activity (PMID: 34593527; PMID: 25516420).
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Cemiplimab + THIO||Cemiplimab THIO||0||1|
|Radiotherapy + Temozolomide + THIO||Radiotherapy THIO Temozolomide||0||0|
|Radiotherapy + THIO||Radiotherapy THIO||0||0|