Drug Detail


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Drug Name XOMA 052
Trade Name
Synonyms Gevokizumab|VPM087
Drug Descriptions

XOMA 052 (gevokizumab) is a monoclonal antibody that targets interleukin-1 beta (IL1B) and reduces the binding affinity of IL1B to IL1R1 and IL-1RAcP receptors, potentially resulting in decreased inflammatory response and reduced ILB1 signaling (PMID: 20410301, PMID: 24194526, PMID: 21048425).

CAS Registry Number 1129435-60-4
NCIT ID C97945


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + XOMA 052 Bevacizumab Fluorouracil Irinotecan Leucovorin XOMA 052 0 1
Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + XOMA 052 Bevacizumab Fluorouracil Leucovorin Oxaliplatin XOMA 052 0 1
Cabozantinib + XOMA 052 Cabozantinib XOMA 052 0 1
Paclitaxel + Ramucirumab + XOMA 052 Paclitaxel Ramucirumab XOMA 052 0 1
XOMA 052 XOMA 052 0 1

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