Drug Detail


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Drug Name CFI-400945
Trade Name
Drug Descriptions

CFI-400945 is a selective Polo-like kinase 4 (PLK4) inhibitor that inhibits cell division and induces apoptosis in tumor cells (PMID: 25043604, PMID: 31303643).

CAS Registry Number 1338806-76-0
NCIT ID C111990


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + CFI-400945 Azacitidine CFI-400945 0 1
CFI-400945 CFI-400945 1 4
CFI-400945 + Decitabine CFI-400945 Decitabine 0 1
CFI-400945 + Durvalumab CFI-400945 Durvalumab 0 1

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