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Drug Name FANG vaccine
Trade Name
Synonyms Vigil|bi-shRNA-furin/GMCSF-expressing autologous tumor cell vaccine
Drug Descriptions

Vigil (FANG vaccine) is a combination of autologous tumor cells expressing recombinant human granulocyte macrophage-colony stimulating factor (GM-CSF) and RNAi against furin convertase. FANG stimulates cell maturation through GM-CSF and prevents GM-CSF degradation by Tgfb1 and Tgfb2 (PMID: 22186789).

DrugClasses
CAS Registry Number NA
NCIT ID C90552

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + FANG vaccine Atezolizumab FANG vaccine 0 1
Bevacizumab + FANG vaccine Bevacizumab FANG vaccine 0 1
Durvalumab + FANG vaccine Durvalumab FANG vaccine 0 1
FANG vaccine FANG vaccine 0 4
FANG vaccine + Irinotecan + Temozolomide FANG vaccine Irinotecan Temozolomide 0 2
FANG vaccine + Nivolumab FANG vaccine Nivolumab 0 1


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