Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name FANG vaccine
Trade Name Vigil
Synonyms bi-shRNA-furin/GMCSF-expressing autologous tumor cell vaccine
Drug Descriptions

Vigil (FANG vaccine) is a combination of autologous tumor cells expressing recombinant human granulocyte macrophage-colony stimulating factor (GM-CSF) and RNAi against furin convertase. FANG stimulates cell maturation through GM-CSF and prevents GM-CSF degradation by Tgfb1 and Tgfb2 (PMID: 22186789).

DrugClasses

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + FANG vaccine Atezolizumab FANG vaccine 0 1
Bevacizumab + FANG vaccine Bevacizumab FANG vaccine 0 1
Durvalumab + FANG vaccine Durvalumab FANG vaccine 0 1
FANG vaccine FANG vaccine 0 4
FANG vaccine + Irinotecan + Temozolomide FANG vaccine Irinotecan Temozolomide 0 1
FANG vaccine + Nivolumab FANG vaccine Nivolumab 0 1


Additional content available in CKB BOOST