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Drug Name Oleclumab
Trade Name
Synonyms MEDI9447
Drug Descriptions

Oleclumab (MEDI9447) is a monoclonal antibody against NT5E (CD73), resulting in activation of an anti-tumor immune response by preventing the conversion of AMP to adenosine in the tumor microenvironment (PMID: 27622077).

DrugClasses Adenosine Targeting 18 CD73 Antibody 7

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AZD4635 + Oleclumab AZD4635 Oleclumab 0 2
Carboplatin + Durvalumab + Oleclumab Carboplatin Durvalumab Oleclumab 0 0
Cisplatin + Durvalumab + Oleclumab Cisplatin Durvalumab Oleclumab 0 0
Durvalumab + Fluorouracil + Leucovorin + Oleclumab + Oxaliplatin Durvalumab Fluorouracil Leucovorin Oleclumab Oxaliplatin 0 2
Durvalumab + Gemcitabine + Nab-paclitaxel + Oleclumab Durvalumab Gemcitabine Nab-paclitaxel Oleclumab 0 1
Durvalumab + Gemcitabine + Oleclumab Durvalumab Gemcitabine Oleclumab 0 0
Durvalumab + IPH5201 + Oleclumab Durvalumab IPH5201 Oleclumab 0 1
Durvalumab + Nab-paclitaxel + Oleclumab Durvalumab Nab-paclitaxel Oleclumab 0 0
Durvalumab + Oleclumab Durvalumab Oleclumab 0 6
Durvalumab + Oleclumab + Paclitaxel Durvalumab Oleclumab Paclitaxel 0 1
Durvalumab + Oleclumab + Pemetrexed Durvalumab Oleclumab Pemetrexed 0 0
Fluorouracil + Leucovorin + Oleclumab + Oxaliplatin Fluorouracil Leucovorin Oleclumab Oxaliplatin 0 1
Gemcitabine + Nab-paclitaxel + Oleclumab Gemcitabine Nab-paclitaxel Oleclumab 0 1
Oleclumab Oleclumab 0 1
Oleclumab + Osimertinib Oleclumab Osimertinib 0 1


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