Drug Detail


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Drug Name AZD4635
Trade Name
Synonyms AZD 4635|AZD-4635
Drug Descriptions

AZD4635 binds to and inhibits the adenosine A2A (ADORA2A) receptor on immune cells, resulting in activation of an anti-tumor immune response by blocking binding of the immunosuppressive metabolite, adenosine (PMID: 29758241, PMID: 32727810).

DrugClasses Adenosine Targeting 19
CAS Registry Number 1321514-06-0
NCIT ID C148039


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AZD4635 AZD4635 0 1
AZD4635 + Cabazitaxel + Durvalumab AZD4635 Cabazitaxel Durvalumab 0 1
AZD4635 + Durvalumab AZD4635 Durvalumab 0 3
AZD4635 + Oleclumab AZD4635 Oleclumab 0 2

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